MINERAL EXCHANGES OF MAN: III. Mineral Metabolism During Treatment of a Case of Polycythemia Vera.
نویسندگان
چکیده
The hemolytic properties of phenylhydrazine and phenylhydrazine hydrochloride were first demonstrated by Hoppe-Seyler (16) in 1884. During the following thirty-four years the drug or its derivatives were used to some extent in the production of experimental anemia in animals, but it was not until 1918 that it achieved a place in human therapeusis through publication of experiments by Eppinger and Kloss (11) who employed it to bring about destruction of erythrocytes in polycythemia vera. Within recent years a number of metabolic studies have been reported by investigators employing phenylhydrazine or its derivatives in the treatment of this disease. These studies have dealt mainly with changes in the physical and chemical properties of the blood, with studies of renal and liver function and of nitrogen metabolism, before, during and after treatment with hemolytic agents. So far as we have been able to ascertain there have been no reports on the mineral exchanges during a period of blood destruction resulting from the administration of phenylhydrazine derivatives to patients with erythremia. For the past three years we have had a patient with polycythemia vera under observation. On two occasions he has been admitted to the hospital for study and on one of these admissions the exchanges of nitrogen, phosphorus, calcium, magnesium and iron were followed during blood destruction.
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 10 4 شماره
صفحات -
تاریخ انتشار 2013